Publication Date
1975
Abstract
The crystal and molecular structure and the absolute configuration of (—)-(S)-warfarin, C19H1604, have been determined by X-ray crystallographic techniques. Crystals of (—)-(S)-warfarin are orthorhombic, space group P212121, with a=10·883 (3), b=9·562 (3), and c=14·902 (5) Å. Solution of the structure was by direct methods, and refinement by least-squares calculations led to a conventional R of 0·053 (Mo Kα data). The molecule crystallizes as the intramolecular hemiketal and thus may be described as (2S,4S)-2,3H-2-methyl-4-phenyl-5-oxobenzopyrano[3,4-e]dihydropyran-2-ol. The absolute configuration was confirmed by recollecting with Cu Kα radiation a group of reflect ions predicted to have the greatest observable Bijvoet differences based on the anomalous scattering of oxygen and the parameters from the refinement with Mo Kα data. A group of 51 Friedel pairs, 86% of which indicate the S enantiomer, gave a 17% decrease in the residual over the R enantiomer. Refinement of the imaginary part of the anomalous dispersion of oxygen gave a value of 0·037 for Δf".
Subjects
Pharmaceutical biotechnology; Pharmaceutical chemistry; Warfarin
Citation: Pilot Scholars Version (Modified MLA Style)
Valente, Edward J.; Trager, W. F.; and Jensen, L. H., "The Crystal and Molecular Structure and Absolute Configuration of (—)-(S)-Warfarin" (1975). Chemistry Faculty Publications and Presentations. 5.
https://pilotscholars.up.edu/chm_facpubs/5
DOI
10.1107/S056774087500427X
Document Type
Journal Article