Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751
Journal of Natural Products, 2013, Volume 76, Issue 10, 1860-1865.
© 2013 American Chemical Society and American Society of Pharmacognosy
Linked version is the final published version.
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated fromthe mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.