SULTAM THIOUREAS SYNTHESIZED VIA AN ALTERNATIVE RING-FORMING REACTION
A method for the synthesis of sultam thioureas via a different 1,4,2-dithiazolidine 1,1-dioxide ring-forming reaction is presented here. The syntheses of nine sultam thioureas were achieved in 53–81% yield by reacting N-substituted chloromethanesulfonamides with thiocarbamoyl isothiocyanates, which were formed in situ from the reaction of 5-(disubstituted amino)-3H-1,2,4-dithiazole-3-thiones with triphenylphosphine. Importantly, this method successfully allowed the substituent of the ring nitrogen atom to be varied. Additionally, the structures of four sultam thioureas were confirmed by x-ray diffraction.
Author Supplied Keywords
Antiviral agents, Chloromethanesulfonamides, Heterocycles, Medicinal chemistry, Sultam thioureas
Nitrogen compounds; Organic chemistry; Organic compounds--Synthesis
Citation: Pilot Scholars Version (Modified MLA Style)
Li, Victoria; Le, Diane N.; Valente, Edward J.; and Wood, Warren J. L., "SULTAM THIOUREAS SYNTHESIZED VIA AN ALTERNATIVE RING-FORMING REACTION" (2015). Chemistry Faculty Publications and Presentations. Paper 31.
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