Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated fromthe mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
Alkaloids; Endophytic fungi; Fungal metabolites
Citation: Pilot Scholars Version (Modified MLA Style)
Wijeratne, E. M. Kithsiri; He, Hongping; Franzblau, Scott; Hoffman, Angela; and Gunatilaka, A. A. Leslie, "Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751" (2013). Chemistry Faculty Publications and Presentations. Paper 25.
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