Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M. Kithsiri Wijeratne
Hongping He
Scott Franzblau
Angela Hoffman, University of Portland
A. A. Leslie Gunatilaka

Journal of Natural Products, 2013, Volume 76, Issue 10, 1860-1865.

© 2013 American Chemical Society and American Society of Pharmacognosy

Linked version is the final published version.

Abstract

Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated fromthe mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.