A Model Study toward the Concise Synthesis of Bromotyrosine-Derived Spiroisoxazoline Natural Products and Analogous Core Structures
A model study of the first nonaromatic ring based approach toward α-hydroxyspiroisoxazolines resembling the bromotyrosine-derived natural product and analogous spiroisoxazoline core structures was implemented.The desired molecular architecture was achieved through the multifunctionalization of a key 1,3-diketo spiroisoxazoline.Our strategy could serve as an efficient alternative to previously developed approaches that involve aromatic ring oxidation as the essential step to synthesize this class of natural products.
Author Supplied Keywords
Natural products;Heterocycles; Spiro compounds; Synthetic methods; Multifunctionalization; Cyclization
Citation: Pilot Scholars Version (Modified MLA Style)
Das, Prasanta; Valente, Edward J.; and Hamme II, Ashton T., "A Model Study toward the Concise Synthesis of Bromotyrosine-Derived Spiroisoxazoline Natural Products and Analogous Core Structures" (2014). Chemistry Faculty Publications and Presentations. Paper 23.
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